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Highlights
- BIOA B advances its Phase 2a EXIST trial after interim data shows exidavnemab is well tolerated.
- The company decided to initiate two additional cohorts testing higher doses in Parkinson’s disease and MSA patients.
- BIOA B exidavnemab targets aggregated alpha-synuclein, linked to synucleinopathy-related neurodegeneration.
BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) based in Sweden, focuses on research and development of therapies aimed at neurodegenerative diseases. The company previously partnered with Eisai on the development of Leqembi® (lecanemab), an approved treatment for early Alzheimer’s disease. Beyond Alzheimer’s, BioArctic is pursuing research programs in conditions such as ALS, Parkinson’s disease, and enzyme deficiency disorders.
The company has announced that its clinical Phase 2a study, known as EXIST, will proceed to additional dosing cohorts following an interim safety review. The evaluation of the first cohort, involving a lower dose of its investigational monoclonal antibody exidavnemab in patients with Parkinson’s disease, indicated that the treatment was safe and well tolerated.
The EXIST trial is assessing exidavnemab as a potential disease-modifying therapy for synucleinopathies, including Parkinson’s disease and Multiple System Atrophy (MSA). Based on the safety data, two new cohorts will now be initiated to examine a higher dose of exidavnemab in patients with both conditions.
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