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Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania.
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A unique technical analysis driven score developed by Kalkine showing momentum in stock prices based on select technical indicators identified.
Madrigal Pharmaceuticals develops liver-directed thyroid hormone receptor beta agonists led by resmetirom for NASH and related chronic liver diseases. Long-term growth may be driven by successful late-stage trial outcomes, regulatory approval, and commercialization of a therapy for a large unmet NASH market.
Key risks include clinical or regulatory failure for the lead candidate, substantial cash burn and potential need for financing, competitive pressure in NASH drug development, and uncertain reimbursement.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -288.28M | -465.89M | -373.63M | -295.35M | -241.85M |
| Net income | -288.28M | -465.89M | -373.63M | -299.31M | -241.08M |
| Selling general administrative | 813.83M | 435.06M | 108.15M | 48.13M | 37.32M |
| Selling and marketing expenses | - | - | 108.04M | - | - |
| Gross profit | 902.25M | 173.90M | 0.00M | - | 0.27M |
| Reconciled depreciation | 1.51M | 1.10M | 0.53M | 0.47M | 0.41M |
| Ebit | -265.98M | -451.22M | -360.92M | -293.57M | -242.89M |
| Ebitda | -264.47M | -450.12M | -360.39M | -291.39M | -242.48M |
| Depreciation and amortization | 1.51M | 1.10M | 0.53M | 2.19M | 0.41M |
| Non operating income net other | - | - | - | 2.19M | 0.36M |
| Operating income | -300.10M | -497.88M | -380.50M | -293.57M | -242.48M |
| Other operating expenses | 1258.50M | 678.01M | 380.50M | 293.57M | 242.48M |
| Interest expense | 22.31M | 14.67M | 12.71M | 3.96M | 1.04M |
| Interest income | 37.36M | 46.65M | 19.58M | 2.19M | 0.36M |
| Net interest income | 15.05M | 31.98M | 6.87M | -1.78M | 0.36M |
| Income tax expense | - | -465.89M | - | 3.96M | -0.77M |
| Total revenue | 958.40M | 180.13M | 0.00M | 0.00M | 0.04M |
| Total operating expenses | 1202.35M | 671.77M | 380.50M | 293.57M | 242.48M |
| Cost of revenue | 56.15M | 6.23M | 0.53M | - | - |
| Total other income expense net | 11.81M | 31.98M | 6.87M | -1.78M | 0.64M |
| Net income from continuing ops | -288.28M | -465.89M | -373.63M | -295.35M | -242.12M |
| Net income applicable to common shares | - | - | - | -295.35M | -241.85M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 1259.59M | 1042.25M | 640.55M | 362.57M | 273.33M |
| Intangible assets | 7.38M | 4.73M | - | - | - |
| Other current assets | 52.89M | 18.79M | 3.15M | 2.60M | 1.34M |
| Total liab | 656.90M | 287.86M | 235.21M | 165.18M | 77.22M |
| Total stockholder equity | 602.69M | 754.38M | 405.33M | 197.39M | 196.11M |
| Other current liab | 260.39M | 124.69M | 89.98M | 91.46M | 55.05M |
| Common stock | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Capital stock | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings | -2090.47M | -1802.18M | -1336.29M | -962.66M | -667.31M |
| Other assets | - | - | 0.00M | - | - |
| Cash | 198.69M | 100.02M | 99.92M | 331.55M | 36.27M |
| Total current liabilities | 310.29M | 169.28M | 118.55M | 115.89M | 76.84M |
| Net debt | 155.67M | 19.55M | 17.28M | -281.66M | -35.47M |
| Short term debt | 1.02M | 0.98M | 0.53M | 0.60M | 0.41M |
| Short long term debt total | 354.36M | 119.57M | 117.19M | 49.89M | 0.80M |
| Other stockholder equity | 2692.28M | 2556.09M | 1741.15M | 1160.08M | 863.50M |
| Property plant equipment | - | - | - | 0.60M | 1.65M |
| Total current assets | 1245.77M | 1032.93M | 637.28M | 361.37M | 271.68M |
| Net tangible assets | - | - | - | 197.39M | 196.11M |
| Short term investments | 784.87M | 826.23M | 534.22M | 27.23M | 234.08M |
| Net receivables | 134.48M | 53.82M | - | - | - |
| Long term debt | 339.88M | 117.57M | 115.48M | 49.29M | - |
| Inventory | 74.84M | 34.07M | - | - | - |
| Accounts payable | 48.88M | 43.60M | 28.04M | 23.83M | 21.38M |
| Accumulated other comprehensive income | 0.87M | 0.47M | 0.47M | -0.03M | -0.08M |
| Common stock total equity | - | - | - | 0.00M | 0.00M |
| Retained earnings total equity | - | - | - | -962.66M | -667.31M |
| Non currrent assets other | - | - | - | 1.20M | 0.80M |
| Non current assets total | 13.82M | 9.32M | 3.27M | 1.20M | 1.65M |
| Capital lease obligations | 7.75M | 2.00M | 1.71M | 0.60M | 0.80M |
| Long term debt total | - | - | - | 49.29M | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 35.79M | -274.39M | -502.52M | 206.69M | -4.85M |
| Change to liabilities | - | - | - | 38.86M | 20.36M |
| Total cashflows from investing activities | 32.32M | -274.39M | - | 206.69M | -5.05M |
| Net borrowings | 228.34M | 0.00M | - | 49.11M | 50.00M |
| Total cash from financing activities | 255.98M | 735.06M | 595.12M | 313.45M | 171.24M |
| Change to operating activities | - | - | - | 35.15M | 10.29M |
| Net income | -288.28M | -465.89M | -373.63M | -295.35M | -241.85M |
| Change in cash | 98.76M | 5.10M | -231.63M | 295.28M | -17.73M |
| Begin period cash flow | 105.02M | 99.92M | 331.55M | 36.27M | 54.00M |
| End period cash flow | 203.78M | 105.02M | 99.92M | 331.55M | 36.27M |
| Total cash from operating activities | -189.55M | -455.57M | -324.23M | -224.86M | -183.92M |
| Issuance of capital stock | 0.00M | 397.49M | 260.19M | 255.38M | 170.21M |
| Depreciation | 4.72M | 0.70M | 0.53M | 0.47M | 0.41M |
| Other cashflows from investing activities | -8.97M | 19.09M | - | - | - |
| Change to inventory | -36.98M | -34.07M | - | - | - |
| Change to account receivables | -80.65M | -53.82M | - | - | - |
| Other cashflows from financing activities | - | 337.57M | -0.36M | 107.18M | 1.03M |
| Change to netincome | - | - | - | 31.62M | 26.87M |
| Capital expenditures | 0.47M | 1.46M | 1.48M | 0.22M | 0.21M |
| Cash flows other operating | - | - | - | -1.26M | 0.46M |
| Cash and cash equivalents changes | - | - | - | 295.28M | -17.73M |
| Change in working capital | -8.50M | -72.34M | -3.28M | 37.60M | 30.65M |
| Stock based compensation | 98.13M | 79.88M | 49.73M | 31.62M | 26.87M |
| Other non cash items | 4.38M | 2.09M | 6.62M | 0.80M | 7.32M |
| Free cash flow | -190.02M | -457.03M | -325.71M | -225.07M | -184.13M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| MDGL Madrigal Pharmaceuticals Inc |
2.59 0.59% |
440.33 | - | 81.97 | 9.42 | 23.11 | 9.04 | -8.32 |
| NVO Novo Nordisk A/S |
-0.46 1.18% |
38.67 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
3.54 0.68% |
521.03 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
8.43 1.04% |
816.10 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
790.15 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania.
1001 Conshohocken State Road, West Conshohocken, PA, United States, 19428
267 824 2827
915
| Name | Title | Year Born |
|---|---|---|
| Dr. Paul A. Friedman M.D. | Chairman & CEO | 1943 |
| Dr. Rebecca A. Taub M.D. | Founder, Chief Medical Officer, Pres of R&D and Director | 1952 |
| Mr. Alex G. Howarth | Sr. VP & CFO | 1969 |
| Mr. Brian J. Lynch J.D. | Sr. VP & Gen. Counsel | 1962 |
| Mr. Remy Sukhija | Sr. VP & Chief Commercial Officer | 1972 |
| Dr. Kianoush Motesharei Ph.d. | Sr. VP of Bus. & Corp. Devel. | 1970 |
| Mr. Edward Chiang | Sr. VP of Clinical & Technical Operations | NA |
| Mr. Thomas W. Hare | Sr. VP of Clinical Management | NA |
| Dr. Robert E. Waltermire Ph.D. | Chief Pharmaceutical Devel. Officer | 1964 |
| Dr. Stephen Dodge M.B.A., Pharm.D. | Sr. VP of Global Medical Affairs | NA |
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