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Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of masked immuno-oncology therapies. The company's pipeline includes XTX501, a bispecific PD-1 / masked IL-2, for patients with metastatic non-small cell lung cancer; Efarindodekin alfa, an investigational, masked IL-12, that is in Phase 2 clinical trial for patients with advanced solid tumors; and Vilastobart, an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody. The company was founded in 2016 and is headquartered in Waltham, Massachusetts.
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| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -35.04M | -58.24M | -76.40M | -88.22M | -75.80M |
| Net income | -35.04M | -58.24M | -76.40M | -87.30M | -74.30M |
| Selling general administrative | 29.71M | 24.78M | 27.00M | 29.95M | 23.86M |
| Selling and marketing expenses | - | - | 1.90M | - | - |
| Gross profit | 42.23M | 6.34M | -1.90M | - | - |
| Reconciled depreciation | 1.54M | 1.64M | 1.94M | 1.85M | 1.50M |
| Ebit | -35.04M | -59.65M | -76.40M | -91.00M | -76.54M |
| Ebitda | -33.49M | -58.00M | -74.50M | -89.15M | -75.04M |
| Depreciation and amortization | 1.54M | 1.64M | 1.90M | 1.85M | 1.50M |
| Non operating income net other | - | - | - | 0.93M | -0.76M |
| Operating income | -41.98M | -60.58M | -79.13M | -89.15M | -75.04M |
| Other operating expenses | 85.75M | 66.93M | 79.13M | 89.15M | 75.04M |
| Interest expense | - | 0.10M | 0.13M | -0.93M | 0.76M |
| Income tax expense | - | - | -0.93M | -0.93M | -1.50M |
| Total revenue | 43.77M | 6.34M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 84.21M | 66.93M | 79.13M | 89.15M | 75.04M |
| Cost of revenue | 1.54M | 1.64M | 1.90M | - | - |
| Total other income expense net | 6.95M | 2.34M | 2.73M | 0.93M | -0.76M |
| Net income from continuing ops | -35.04M | -58.24M | -81.22M | -88.22M | -75.80M |
| Net income applicable to common shares | - | - | - | -88.22M | -75.80M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 154.69M | 71.08M | 60.93M | 139.16M | 218.06M |
| Other current assets | 2.50M | 4.94M | 3.42M | 4.11M | 4.46M |
| Total liab | 119.41M | 53.48M | 24.10M | 33.52M | 32.63M |
| Total stockholder equity | 35.27M | 17.60M | 36.83M | 105.65M | 185.43M |
| Other current liab | 11.74M | 9.98M | 10.50M | 10.41M | 0.08M |
| Common stock | 36.89M | 0.01M | 0.00M | 0.00M | 0.00M |
| Capital stock | 0.00M | 0.01M | - | 0.00M | 0.00M |
| Retained earnings | -418.79M | -383.75M | -325.51M | -249.11M | -160.89M |
| Other liab | - | - | - | - | 32.63M |
| Other assets | - | - | - | 1.61M | 231.66M |
| Cash | 137.53M | 55.29M | 44.70M | 120.39M | 198.05M |
| Total current liabilities | 56.27M | 27.26M | 15.96M | 21.12M | 12.78M |
| Current deferred revenue | 40.02M | 13.52M | - | - | 8.75M |
| Net debt | -130.58M | -47.15M | -32.15M | -100.45M | -177.52M |
| Short term debt | 1.34M | 1.19M | 4.41M | 7.58M | 0.80M |
| Short long term debt | - | - | - | 6.67M | - |
| Short long term debt total | 6.95M | 8.14M | 12.55M | 19.94M | 20.54M |
| Other stockholder equity | 417.17M | 401.35M | 362.34M | 354.75M | 346.31M |
| Property plant equipment | - | - | - | 7.25M | 13.60M |
| Total current assets | 145.03M | 60.23M | 48.13M | 124.50M | 202.52M |
| Net tangible assets | - | - | - | 105.65M | 185.43M |
| Net receivables | 5.00M | - | - | 0.27M | 0.39M |
| Long term debt | - | - | - | 3.17M | 9.63M |
| Accounts payable | 3.17M | 2.57M | 1.05M | 3.12M | 3.14M |
| Accumulated other comprehensive income | - | - | - | - | -218.06M |
| Common stock total equity | - | - | - | 0.00M | 0.00M |
| Retained earnings total equity | - | - | - | -249.11M | -160.89M |
| Non currrent assets other | 1.81M | 1.78M | 0.01M | 1.83M | 1.95M |
| Non current assets total | 9.66M | 10.84M | 12.80M | 14.67M | 15.54M |
| Capital lease obligations | 6.95M | 8.14M | - | 10.11M | 10.91M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | -0.04M | -0.99M | -1.87M | -1.10M |
| Change to liabilities | - | - | - | 2.07M | -8.44M |
| Total cashflows from investing activities | -0.52M | -0.04M | -0.49M | -1.87M | -1.10M |
| Net borrowings | 0.00M | -3.38M | -6.75M | -0.09M | -0.03M |
| Total cash from financing activities | 87.78M | 29.20M | -6.55M | -0.07M | 260.67M |
| Change to operating activities | - | - | - | 1.52M | -8.98M |
| Net income | -35.04M | -58.24M | -76.40M | -88.22M | -75.80M |
| Change in cash | 82.27M | 10.78M | -75.68M | -77.66M | 178.82M |
| Begin period cash flow | 57.07M | 46.29M | 120.39M | 199.61M | 20.79M |
| End period cash flow | 139.34M | 57.07M | 44.70M | 121.95M | 199.61M |
| Total cash from operating activities | -4.99M | -18.38M | -68.62M | -75.72M | -80.75M |
| Issuance of capital stock | 40.66M | 6.83M | 0.00M | 0.00M | 261.25M |
| Depreciation | 1.54M | 1.64M | 1.90M | 1.85M | 1.50M |
| Change to account receivables | -5.00M | - | - | - | - |
| Sale purchase of stock | 2.81M | - | 0.19M | 0.02M | 261.53M |
| Other cashflows from financing activities | 87.78M | 25.75M | 0.20M | 0.02M | 145.39M |
| Change to netincome | - | - | - | 8.65M | 5.15M |
| Capital expenditures | 0.52M | 0.04M | 0.49M | 1.87M | 1.10M |
| Cash flows other operating | - | - | - | -0.07M | -3.17M |
| Cash and cash equivalents changes | - | - | - | -77.66M | 178.82M |
| Change in working capital | 25.12M | 31.78M | -1.66M | 2.00M | -11.80M |
| Stock based compensation | 6.94M | 6.43M | 7.38M | 8.42M | 4.96M |
| Other non cash items | -3.56M | 0.00M | 0.16M | 0.22M | 0.17M |
| Free cash flow | -5.51M | -18.41M | -69.11M | -77.59M | -81.85M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| XLO Xilio Development Inc |
-0.37 4.37% |
8.10 | - | - | 0.93 | 0.81 | 10.21 | -0.11 |
| NVO Novo Nordisk A/S |
-0.54 1.32% |
40.55 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-2.37 0.43% |
544.66 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
-2.77 0.29% |
956.64 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of masked immuno-oncology therapies. The company's pipeline includes XTX501, a bispecific PD-1 / masked IL-2, for patients with metastatic non-small cell lung cancer; Efarindodekin alfa, an investigational, masked IL-12, that is in Phase 2 clinical trial for patients with advanced solid tumors; and Vilastobart, an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody. The company was founded in 2016 and is headquartered in Waltham, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Dr. Rene Russo BCPS, Pharm.D, Pharm.D. | CEO & Director | 1975 |
| Dr. Martin H. Huber M.D. | Pres and Head of R&D | 1961 |
| Dr. Uli Bialucha Ph.D. | Chief Scientific Officer | NA |
| Mr. Christopher Frankenfield | Chief Legal & Admin. Officer | NA |
| Julissa Viana | VP of Corp. Communications | NA |
| Mr. Bill Avery Ph.D. | Sr. VP of Nonclinical Devel. | NA |
| Ms. Stacey J. Davis | Chief Bus. Officer | NA |
| Dr. Rene Russo BCPS, Pharm.D. | President, CEO & Director | 1975 |
| Mr. Kevin M. Brennan | Senior VP of Finance & Accounting | 1970 |
| Mr. Christopher Frankenfield | Chief Operating Officer | NA |
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