FMR LLC and Abigail P. Johnson filed Amendment No. 2 to a Schedule 13G with the SEC on November 4, 2026, disclosing beneficial ownership of common stock in Praxis Precision Medicines Inc. (NASDAQ:PRAX) as of September 30, 2026.

Key Highlights

  • Aggregate beneficial ownership: FMR LLC and Abigail P. Johnson each reported 2,565,828.27 shares of Praxis Precision Medicines common stock beneficially owned.
  • Percent of class: The reported holdings represent 9.2% of the outstanding common stock, according to the filing.
  • Sole voting power (FMR LLC): FMR LLC reported sole voting power over 2,561,602.06 shares, with zero shared voting power.
  • Sole dispositive power: Both FMR LLC and Abigail P. Johnson reported sole dispositive power over 2,565,828.27 shares, with no shared dispositive power.
  • Triggering event date: The filing identifies September 30, 2026 as the date of the event requiring this statement.
  • Third-party interests: The filing states that one or more other persons have the right to receive or direct receipt of dividends or sale proceeds, but no single other person's interest exceeds 5% of total outstanding common stock.

FMR LLC and Abigail P. Johnson Disclose Combined 9.2% Position as of September 30, 2026

According to the Schedule 13G Amendment No. 2 filed on November 4, 2026, FMR LLC, a Delaware-organized holding company, and Abigail P. Johnson, a United States citizen, jointly disclosed their beneficial ownership positions in the common stock of Praxis Precision Medicines Inc. The triggering date for the filing was September 30, 2026, and the CUSIP number identified for the securities is 74006W207.

FMR LLC reported sole voting power over 2,561,602.06 shares and sole dispositive power over 2,565,828.27 shares. Abigail P. Johnson reported zero sole or shared voting power, but reported sole dispositive power over the same 2,565,828.27 shares. Both filers reported zero shared voting power and zero shared dispositive power. The aggregate amount beneficially owned by each reporting person is listed as 2,565,828.27 shares, equating to 9.2% of the class, as stated in the filing.

The filing was signed by Stephanie J. Brown, acting under a Power of Attorney on behalf of both FMR LLC and Abigail P. Johnson. The certification included in the filing states that "the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer." The filing also references Exhibit 99 for identification of subsidiaries that acquired the reported securities.

What Was Disclosed

FMR LLC and Abigail P. Johnson filed an amended Schedule 13G disclosing combined beneficial ownership of 2,565,828.27 shares, or 9.2%, of Praxis Precision Medicines Inc. common stock, based on holdings as of September 30, 2026.